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Bovine derived in vitro cultures generate heterogeneous populations of antigen presenting cells
(Frontiers Media, 2019)
Antigen presenting cells (APC) of the mononuclear phagocytic system include dendritic cells (DCs) and macrophages (Macs) which are essential mediators of innate and adaptive immune responses. Many of the biological functions ...
Antigen presentation unfolded: identifying convergence points between the UPR and antigen presentation pathways
(Elsevier, 2018-06)
The unfolded protein response (UPR) is an adaptive response meant to restore endoplasmic reticulum homeostasis in conditions of ER stress that subvert the folding capacity of the cell. Over the past few years, it has become ...
Dexamethasone and Monophosphoryl Lipid A-Modulated Dendritic Cells Promote Antigen-Specific Tolerogenic Properties on Naive and Memory CD4(+) T cells
(Frontiers Media, 2016)
Tolerogenic dendritic cells (DCs) are a promising tool to control T cell-mediated autoimmunity. Here, we evaluate the ability of dexamethasone-modulated and monophosphoryl lipid A (MPLA)-activated DCs [MPLA-tolerogenic DCs ...
Activation mechanisms of invariant natural killer T cells (iNKTs)
(Univ Antioquia, Fac Med, 2016)
A great amount of knowledge on natural killer T cells (iNKTs) is now available, but a consensus about their activation mechanisms has not been reached. These cells recognize different glycolipid antigens through the CD1d ...
Immunization with antigen-pulsed dendritic cells significantly improves the immune response to weak self-antigens
(ELSEVIER GMBH, 2005-09-02)
Dendritic cells (DCs) are the only professional antigen-presenting cells endowed with the ability to stimulate naı¨ve T
cells and initiate a primary immune response. For this reason, DC-based immunization has been shown ...
Synthetic glycolipid activators of natural killer T cells as immunotherapeutic agents
(Nature Publishing Group, 2016)
Certain types of glycolipids have been found to have remarkable immunomodulatory properties as a result of their ability to activate specific T lymphocyte populations with an extremely wide range of immune effector properties. ...
Changes in nuclear distribution of large tumor antigen correlate with the proliferative activity of simian virus 40-transformed cells
(1989)
A correlation between intranuclear distribution of large tumor antigen (T-ag) and proliferative activity in Simian virus 40 (SV40)-transformed cells has been established. Nuclear T-ag was cytochemically detected by the ...
Analysis of protease activity in live antigen-presenting cells shows regulation of the phagosomal proteolytic contents during dendritic cell activation
(2002)
Here, we describe a new approach designed to monitor the proteolytic activity of maturing
phagosomes in live antigen-presenting cells. We find that an ingested particle sequentially encounters
distinct protease activities ...
Dead tumor cells expressing infectious salmon anemia virus fusogenic protein favor antigen cross-priming in vitro
(Frontiers media SA, 2017)
Antigen cross-presentation is a crucial step in the assembly of an antitumor immune response leading to activation of naive CD8 T cells. This process has been extensively used in clinical trials, in which dendritic cells ...
Tumor cell lysates as immunogenic sources for cancer vaccine design
(Landes Bioscience, 2014)
© 2014 Taylor & Francis Group, LLC Autologous dendritic cells (DCs) loaded with tumor-associated antigens (TAAs) are a promising immunological tool for cancer therapy. These stimulate the antitumor response and immunological ...